How to administer Fresh Frozen Plasma (FFP) - Quick Guide


  • Fresh Frozen Plasma (FFP): 180-340mL
  • Paediatric FFP: 45-90mL (4 doses can be obtained from a single donation)
A unit of FFP

ABO & RhD Compatibility


  • Plasma components should be ABO compatible as follows:
    • a group O patient can receive FFP of any ABO group
    • a group A patient can receive A or AB FFP
    • a group B patient can receive B or AB FFP
    • a group AB patient can receive only AB FFP


  • No anti-D immunoglobulin need be given if Rh(D) negative patients receive Rh(D) positive FFP or cryoprecipitate.
  • Although frozen plasma components may contain small amounts of red cell stroma, sensitisation following transfusion of Rh(D) positive units is most unlikely, as stroma is less immunogenic than intact red cells. Therefore Cryoprecipitate of any Rh(D) type may be given regardless of the Rh(D) type of the recipient. Contact Blood Bank if you are not sure.


  • Once thawed, must be stored in an appropriately monitored (2-6°C) blood refrigerator according to Blood Bank standards for up to 24 hours.
  • Never store in a drug or food fridge.
  • If the transfusion can not be started within 30 minutes, return the component to a blood refrigerator Bank immediately for appropriate storage.
  • Blood Bank will only accept the unit back into stock if returned within 30 minutes of issue from Blood Bank.
  • Once issued, Fresh Frozen Plasma should be transfused as soon as possible.


  • Use a standard blood infusion set which has a 170-200 micron filter
  • A new blood infusion set is required at commencement. Maximum hang-time is 12 hours. Upon completion of the transfusion the blood infusion set must be flushed and disconnected. If further IV therapy is required a new infusion set must be used. If transfusing platelets ensure they are administered via a new infusion set and before red cells. Each infusion set may enable 2-4 units to be transfused during a routine transfusion. During a massive transfusion 8-10 units may be possible prior to replacement.
  • All fresh components, including FFP, are leucodepleted at source by NZBS. No bedside leucodepletion is necessary.


  • Approved infusion pump devices may be used.

Rate and Duration

  • Paediatrics:
    • in a non-bleeding patient: infuse at 10-20mL/kg/hr
    • resuscitation: rapid infusion based on the patient's haemodynamics
  • Adults:
    • in a non-bleeding patient: most adults will tolerate one unit of FFP every 90 minutes. Consider a slower rate in patients with or at risk of congestive cardiac failure.
    • resuscitation: rapid infusion based on the patient's haemodynamics
  • Infusion of all components should be completed within 4 hours of leaving refrigerated storage.



  • DO NOT add medication to FFP or Cryoprecipitate
  • DO NOT use 5% Dextrose solutions (may induce haemolysis)
  • DO NOT use Lactated Ringer's or other balanced salt solutions that contain Calcium, as this may induce clot formation in the blood bag and / or administration set.


Dose Calculator

This calculator will compute the dose of FFP your patient may need.

Patient's weight (kg)

No. of units FFP for a standard therapeutic dose (15mL/kg)

No. of mls FFP for a standard therapeutic dose (15mL/kg)

Note: the volume of each unit varies. For paediatric patients, For paediatric patients, request the number of mL prescribed from Blood Bank.

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